Effect of excipient properties and blend ratio on the compression properties of dry granulated particles prepared from microcrystalline cellulose and lactose
Maryam Tofiq
<p>In this study, the effect of a systematically varied excipient ratio of a plastic and a brittlematerial, i.e.,microcrystalline<br>cellulose (MCC) and crystalline α-lactose monohydrate (LAC), on the compression properties of dry granulated<br>particleswas investigated. Five powderswith differentMCC:LAC ratios were prepared by drymixing; subsequently,<br>they were formed into slugs that were milled and sieved, giving granules of two size fractions. Two slugging<br>pressures were used, giving granules of different porosity for each powder. Original powders and granules were<br>compressed, and strain-pressure profiles determined. From these profiles, a series of compression parameters<br>were derived using the Heckel, Kawakita, and Adams compression equations.<br>The initial part of the compression profiles of all granulated powders were similar up to a jamming point, after<br>which the compression profiles diverged depending on the granule composition and the slugging pressure. Parameters<br>derived from the Adams and Kawakita equations reflected the differences in compression behavior,<br>while the Heckel parameter did not. Themacroscopic compression stiffening was assessed by the Adams friction<br>parameter which seemed to be controlled by the inner friction of the granules, i.e., their plastic deformation due<br>to inter-particulate flow. The total compressibility, assessed by the Kawakita parameter, was dependent on the<br>initial bulk porosity of the granulations.<br>It is concluded that the composition, microstructure, and packing density of the granules dictated their compression<br>properties, while the granule size and work hardening of primary particles were insignificant.<br></p>
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